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Known hypersensitivitye.ganaphylactic reactions and serious skin reactionsto mefenamic acid or any components of the drug productsee WARNINGSAnaphylactic ReactionsSerious Skin ReactionsHistory of asthmaurticariaor other allergic-type reactions after taking aspirin or other NSAIDsSeveresometimes fatalanaphylactic reactions to NSAIDs have been reported in such patientssee WARNINGSAnaphylactic ReactionExacerbation of Asthma Related to Aspirin SensitivityIn the setting of coronary artery bypass graftCABGsurgerysee WARNINGSCardiovascular Thrombotic Events
Kidney problems can sometimes occur with the use of NSAID medicationsincluding mefenamic acidProblems are more likely to occur if you are dehydratedhave heart failure or kidney diseaseare an older adultor if you take certain medicationssee also Drug Interactions sectionDrink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.
NSAIDsincluding Ponstelcan lead to new onset of hypertension or worsening of pre-existing hypertensioneither of which may contribute to the increased incidence of CV eventsPatients taking angiotensin converting enzymeACEinhibitorsthiazides diureticsor loop diuretics may have impaired response to these therapies when taking NSAIDssee PRECAUTIONSDrug Interactions
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