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Nimodipine is a calcium channel blockerThe contractile processes of smooth muscle cells are dependent upon calcium ionswhich enter these cells during depolarization as slow ionic transmembrane currentsNimodipine inhibits calcium ion transfer into these cells and thus inhibits contractions of vascular smooth muscleIn animal experimentsnimodipine had a greater effect on cerebral arteries than on arteries elsewhere in the body perhaps because it is highly lipophilicallowing it to cross the blood-brain barrierconcentrations of nimodipine as high as 12.5 ng/mL have been detected in the cerebrospinal fluid of nimodipine-treated subarachnoid hemorrhageSAHpatients.
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