You should not use this product if you are allergic to any of the following ingredients colchicine, lactose monohydrate, microcrystalline cellulose, pregelatinised starch, sodium starch glycolate, magnesium stearate.
Information about Colchicine.
No dedicated pharmacokinetic study using colchicine capsules has been conducted in patients with varying degrees of hepatic impairmentColchicine is known to be metabolized in humans and the presence of severe hepatic impairment has been associated with colchicine toxicityHepatic clearance of colchicine may be significantly reduced and plasma half-life prolonged in patients with chronic hepatic impairment.
The first stage of acute colchicine toxicity typically begins within 24 hours of ingestion and includes gastrointestinal symptoms such as abdominal painnauseavomitingdiarrheaand significant fluid lossleading to volume depletionPeripheral leukocytosis may also be seenLife-threatening complications occur during the second stagewhich occurs 24 to 72 hours after drug administrationattributed to multi-organ failure and its associated consequencesDeath usually results from respiratory depression and cardiovascular collapseIf the patient survivesrecovery of multi-organ injury may be accompanied by rebound leukocytosis and alopecia starting about 1 week after the initial ingestionTreatment of colchicine overdose should begin with gastric lavage and measures to prevent shockOtherwisetreatment is symptomatic and supportiveNo specific antidote is knownColchicine is not effectively removed by hemodialysisSee Pharmacokinetics
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Colchicine may cause severe bone marrow depressionagranulocytosisaplastic anaemiathrombocytopeniaThe change in blood counts may be gradual or very suddenAplastic anaemia in particular has a high mortality ratePeriodic checks of the blood picture are essential.
Colchicine is potentially toxic so it is important not to exceed the dose prescribed by a physician with the necessary knowledge and experience.
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