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Get emergency medical help if you have signs of an allergic reaction to methotrexatehivesdifficult breathingswelling in your face or throator a severe skin reactionfeversore throatburning in your eyesskin painred or purple skin rash that spreads and causes blistering and peeling
Drink plenty of fluids while taking this medication unless your doctor tells you otherwiseDoing so helps your kidneys to remove the drug from your body and avoid some of the side effects.
Methotrexate can make you more likely to get infections or may worsen any current infectionsThereforewash your hands well to prevent the spread of infectionAvoid contact with people who have infections that may spread to otherssuch as chickenpoxmeaslesfluConsult your doctor if you have been exposed to an infection or for more details.
Before having surgerytell your doctor or dentist about all the products you useincluding prescription drugsnonprescription drugsand herbal products
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these studies were not designed to demonstrate the specific contribution of high dose methotrexate leucovorin rescue therapy to the efficacy of the combination.