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A very serious allergic reaction to this drug is unlikelybut seek immediate medical attention if it occursSymptoms of a serious allergic reaction may includerashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.
As with other antipsychoticscaution should be exercised when clozapine is prescribed with medicines known to increase QTc intervalor causing electrolyte imbalance.
Orthostatic hypotensionwith or without syncopecan occur during Clozaril treatmentRarelycollapse can be profound and may be accompanied by cardiac and/or respiratory arrestSuch events are more likely to occur with concurrent use of a benzodiazepine or any other psychotropic agentsee section 4.5and during initial titration in association with rapid dose escalationon very rare occasions they may occur even after the first doseThereforepatients starting Clozaril treatment require close medical supervisionMonitoring of standing and supine blood pressure is necessary during the first weeks of treatment in patients with Parkinson’s disease.
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caution is advised in patients being administered general anesthesia because of the cns effects of clozaril.